Microphysiological systems (MPS) comprise a number of bioengineering breakthroughs that reproduce organ architecture and function in vitro. Fueled by stem-cell technologies, a broad variety of especially human models and test systems have emerged, which make relevant experimental tools broadly available through international and multidisciplinary collaborations. By bringing together researchers, regulators, funding agencies, and academia, we aim to accelerate the development and adoption of this exciting new technology that will so positively impact all of humanity.